3D X-ray microscopy: analysis of drugs and formulations

In the Bruker AXS webinar series, our managing director Dr.-Ing. Markus J. Heneka spoke as an expert about the application of 3D X-ray tomography in the pharmaceutical industry. The event was viewed very positively by well over 100 registered participants from all over the world.

3D X-ray analysis of foreign particles in medical glass ampoules

A particular challenge is the correct analysis of microparticles inside medical glass ampoules. When the vials are opened, glass breakage often occurs, which can get into the analysis and falsify the result. To solve the problem, our team has developed a new process to non-destructively detect foreign particles in glass ampoules.

Sand in the Gearbox – Abrasive Minerals Invisible in Contaminant Particles?

It is often surprising for our customers when we find hard mineral particles on their components during technical cleanliness analysis. Customers ask: "How can that be? We didn't find anything in our own cleanliness tests." The contamination of hard minerals is so important, because these particles have an abrasive effect and thus massively damage mechanical systems such as gears and motors.

Filmic Contamination Leads to Gearbox Failure

The determination of the technical cleanliness according to VDA-19.1 or ISO-16232 is now an integral part of quality control and error analysis - because the cleanliness of components is decisive for the quality and error-free function of the product. In addition to particles, filmic contamination poses a problem, as the following example from quality assurance in the manufacture of electric drive systems shows.

Successful Confirmation of our ISO-17025 Accreditation

Yesterday we had a working visit from the German Accreditation Body (DAkkS), who audited our management system for ISO-17025 accreditation. Monitoring of this type is carried out by the DAkkS at regular intervals, and our processes are put through their paces.

Analysis of Foreign Particles in Pharmaceutical Powders

A central requirement in the production of pharmaceutical products is the avoidance of visible foreign particles. Our testing laboratory has developed innovative yet simple methods to reliably quantify foreign particles in pharmaceutical powders.

Erroneous Detection of Metallic Particles by Light Microscopy

The identification of metallic particles is an important requirement in cleanliness analysis. In recent years, the light-optical detection of metallic particles has commonly been performed by the means of gloss. On the basis of our laboratory experience, we have found that the light microscopic analysis often leads to incorrect typifications, which can be easily avoided by a material analysis using SEM-EDX.

Tiny Particles – Catastrophic Effect

A German automobile manufacturer recently learned what problems the smallest residual dirt particles can cause: It had to recall numerous vehicles due to engine malfunctions. The reason was manufacturing residues consisting of hard particles, which lead to major engine damage - in the worst case, to burning cars. Hard residual dirt particles usually come from the fine processing of surfaces by glass blasting, vibratory grinding, honing […]

Development of Modern Medicine Supported by Microtomography

A medication, for example a painkiller, should work reliably and always release the active ingredient within a certain period of time. A decisive factor for this is the active ingredient content and reproducible release kinetics. With a micro-CT we can scan tablets non-destructively.